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Mechanistically, multi-omics analyses of cardiac and hepatic tissues revealed that semaglutide exerted these benefits by improving cardiac metabolism, interfering with pro-fibrotic and pro-hypertrophic signals, and by reducing systemic inflammation

The pathophysiology of irritable bowel syndrome (IBS) is heterogeneous, involving a complex interplay of altered gut-brain signaling, visceral hypersensitivity, dysbiosis, immune activation, and psychosocial factors, which vary widely among individuals 1,2

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